Improved synthesis of the epoxy isoprostane phospholipid PEIPC and its reactivity with amines.
نویسندگان
چکیده
An improved synthesis of the naturally occurring hydroxy ketone 1-palmitoyl-2-(5,6)-epoxyisoprostane E 2- sn-glycero-3-phosphocholine (PEIPC) 1, a compound that plays a role in endothelial activation in atherosclerosis, has been carried out using a PMB ether as the key protecting group. Opening of an intermediate with pentylamine shows that the allylic epoxide is the position of attack by nucleophiles.
منابع مشابه
Total synthesis of the epoxy isoprostane phospholipids PEIPC and PECPC.
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ورودعنوان ژورنال:
- Organic letters
دوره 10 19 شماره
صفحات -
تاریخ انتشار 2008